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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPKAPK5
All Species:
23.33
Human Site:
Y189
Identified Species:
42.78
UniProt:
Q8IW41
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IW41
NP_003659.2
473
54220
Y189
T
P
Q
F
T
P
Y
Y
V
A
P
Q
V
L
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001102910
666
74053
Y384
T
P
Q
F
T
P
Y
Y
V
A
P
Q
V
L
E
Dog
Lupus familis
XP_534678
804
89494
Y520
T
P
Q
F
T
P
Y
Y
V
A
P
Q
V
L
E
Cat
Felis silvestris
Mouse
Mus musculus
O54992
473
54134
Y189
T
P
Q
F
T
P
Y
Y
V
A
P
Q
V
L
E
Rat
Rattus norvegicus
Q66H84
384
43204
E147
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521063
278
31941
F48
M
L
C
G
Y
P
P
F
Y
S
K
H
H
S
R
Chicken
Gallus gallus
Q5F3L1
789
89022
F192
D
F
G
L
S
K
E
F
L
T
D
E
N
E
R
Frog
Xenopus laevis
NP_001085020
377
43533
M147
E
R
E
A
S
E
I
M
R
S
I
G
E
A
I
Zebra Danio
Brachydanio rerio
NP_001002336
471
53898
Y189
T
P
Q
F
T
P
Y
Y
V
A
P
Q
V
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49071
359
41383
A129
I
M
H
E
I
C
A
A
V
D
Y
L
H
S
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500006
366
41523
L136
M
S
I
A
H
R
D
L
K
P
E
N
L
L
Y
Sea Urchin
Strong. purpuratus
XP_001194739
473
54175
Y190
T
P
H
F
T
P
Y
Y
V
A
P
Q
V
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZV15
583
64702
S283
K
T
I
D
F
G
L
S
V
F
F
K
P
G
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
70.7
58
N.A.
97.2
34.4
N.A.
57.2
21.1
34
87
N.A.
32.3
N.A.
34.6
56
Protein Similarity:
100
N.A.
70.7
58.3
N.A.
98.7
52.8
N.A.
58.1
35.3
52
94.2
N.A.
49.2
N.A.
52.4
72.3
P-Site Identity:
100
N.A.
100
100
N.A.
100
0
N.A.
6.6
0
0
100
N.A.
6.6
N.A.
6.6
93.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
20
N.A.
20
26.6
20
100
N.A.
6.6
N.A.
13.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
0
8
16
8
0
47
0
0
0
8
0
% A
% Cys:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
0
0
8
0
0
8
8
8
0
0
0
% D
% Glu:
8
0
16
8
8
8
8
8
0
0
8
8
8
8
54
% E
% Phe:
8
8
0
47
8
0
0
16
0
8
8
0
0
0
0
% F
% Gly:
0
0
8
8
0
8
0
0
0
0
0
8
0
16
0
% G
% His:
0
0
16
0
8
0
0
0
0
0
0
8
16
0
0
% H
% Ile:
8
0
16
0
8
0
8
0
8
0
8
0
8
0
8
% I
% Lys:
8
0
0
0
0
8
0
0
8
0
8
8
0
0
0
% K
% Leu:
0
8
0
8
0
0
8
8
8
0
0
8
8
54
0
% L
% Met:
16
8
0
0
0
0
0
8
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% N
% Pro:
0
47
0
0
0
54
8
0
0
8
47
0
8
0
0
% P
% Gln:
0
0
39
0
0
0
0
0
0
0
0
47
0
0
0
% Q
% Arg:
0
8
0
8
0
8
0
0
8
0
8
0
0
0
24
% R
% Ser:
0
8
0
0
16
0
0
8
0
16
0
0
0
16
0
% S
% Thr:
47
16
0
0
47
0
0
0
0
8
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
62
0
0
0
47
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
47
47
8
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _